Dr. Quest gets called to Roswell, New Mexico, by an old friend, Alice Starseer, when she is investigated by shady government agents.
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- Alice Starseer (first appearance)(also flashback)
- Men in black (single appearance)
- Chief man in black (single appearance)
- Alice Starseer's grandfather (also flashback)
- Mrs. Evans (single appearance)
- Virgil (single appearance)
- The Anasazi (single appearance)(no lines)
- Roswell, New Mexico (also flashback)
- Alice Starseer's ranch
- Quest Compound
- Amtrak station
- Springfield, Missouri
- Quinlan, Oklahoma
- Sunray, Texas
- Rankin Air Service
- Quest plane
- Amtrak train
|J.D. Roth||Jonny Quest|
|Michael Benyaer||Hadji Singh|
|Jesse Douglas||Jessie Bannon|
|George Segal||Dr. Benton Quest|
|Robert Patrick||Race Bannon|
|Irene Bedard||Alice Starseer|
|Kathleen Freeman||Mrs. Evans|
|Jim Meskimen||Chief man in black|
|B.J. Ward||Iris the computer|
- CMC is a parody of GMC Motors.
- The Quest Byte was written by Michael Ryan, who also polished the episode's script.
- None known.
- The Real Adventures of Jonny Quest: Season One, Volume One DVD set released on February 17, 2009 by Warner Home Video.
- Return of the Anasazi - cassette tape audio adaptation